Encodes putative eukaryotic homolog of archaebacterial topoisomerase VI subunit B, TOP6B. Is essential for endoreduplication and is involved in cell expansion and cell proliferation.
Computational Description
topoisomerase 6 subunit B (TOP6B); CONTAINS InterPro DOMAIN/s: DNA topoisomerase VI, subunit B, transducer (InterPro:IPR015320), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), Ribosomal protein S5 domain 2-type fold, subgroup (InterPro:IPR014721), ATPase-like, ATP-binding domain (InterPro:IPR003594); Has 873 Blast hits to 542 proteins in 165 species: Archae - 495; Bacteria - 44; Metazoa - 2; Fungi - 2; Plants - 34; Viruses - 0; Other Eukaryotes - 296 (source: NCBI BLink).