Encodes a SU(VAR)3-9 homolog, a SET domain protein (Homology Subgroup V; Orthology Group 1). Known SET domain proteins are involved in epigenetic control of gene expression. There are 10 SUVH genes in Arabidopsis and members of this subfamily of the SET proteins have an additional conserved SRA domain. This protein is a putative histone methyltransferase (predicted to methylate H3K9/20) related to the the Drosophila Su(var)3-9 and mammalian G9a proteins.
Computational Description
SET domain group 21 (SDG21); FUNCTIONS IN: histone methyltransferase activity; INVOLVED IN: regulation of gene expression, epigenetic; LOCATED IN: nucleus; CONTAINS InterPro DOMAIN/s: SET domain (InterPro:IPR001214), AT hook, DNA-binding motif (InterPro:IPR017956), SRA-YDG (InterPro:IPR003105), Pre-SET zinc-binding sub-group (InterPro:IPR003606), Pre-SET domain (InterPro:IPR007728), Post-SET domain (InterPro:IPR003616); BEST Arabidopsis thaliana protein match is: SU(VAR)3-9 homolog 7 (TAIR:AT1G17770.1); Has 4288 Blast hits to 4094 proteins in 395 species: Archae - 0; Bacteria - 274; Metazoa - 2162; Fungi - 458; Plants - 1048; Viruses - 4; Other Eukaryotes - 342 (source: NCBI BLink).