Encodes a bifunctional aspartate kinase/homoserine dehydrogenase. These two activities catalyze the first and the third steps toward the synthesis of the essential amino acids threonine, isoleucine and methionine.
Computational Description
aspartate kinase-homoserine dehydrogenase ii (AK-HSDH II); FUNCTIONS IN: homoserine dehydrogenase activity, aspartate kinase activity; INVOLVED IN: aspartate family amino acid biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aspartate/glutamate/uridylate kinase (InterPro:IPR001048), Homoserine dehydrogenase, catalytic (InterPro:IPR001342), Amino acid-binding ACT (InterPro:IPR002912), Aspartate/homoserine dehydrogenase, NAD-binding (InterPro:IPR005106), Aspartate kinase, conserved site (InterPro:IPR018042), Bifunctional aspartokinase/homoserine dehydrogenase I (InterPro:IPR011147), Aspartate kinase domain (InterPro:IPR001341), NAD(P)-binding domain (InterPro:IPR016040), Homoserine dehydrogenase, conserved site (InterPro:IPR019811); BEST Arabidopsis thaliana protein match is: aspartate kinase-homoserine dehydrogenase i (TAIR:AT1G31230.1); Has 17435 Blast hits to 17108 proteins in 2575 species: Archae - 421; Bacteria - 11654; Metazoa - 7; Fungi - 299; Plants - 259; Viruses - 0; Other Eukaryotes - 4795 (source: NCBI BLink).