Encodes AtCHIP, a new class of E3 ubiquitin ligases with three tetratricopeptide repeats and a U-box domain, structurally similar to the animal CHIP proteins. Plays an important role in plant cellular metabolism under temperature stress conditions. Functions as an E3 ubiquitin ligase of protein phosphatase 2A subunits and alters plant response to abscisic acid treatment.
Computational Description
carboxyl terminus of HSC70-interacting protein (CHIP); FUNCTIONS IN: ubiquitin-protein ligase activity; INVOLVED IN: response to salt stress, response to temperature stimulus, response to abscisic acid stimulus, protein ubiquitination; LOCATED IN: ubiquitin ligase complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide TPR-1 (InterPro:IPR001440), Tetratricopeptide-like helical (InterPro:IPR011990), U box domain (InterPro:IPR003613), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: protein phosphatase 5.2 (TAIR:AT2G42810.2); Has 6721 Blast hits to 5903 proteins in 442 species: Archae - 38; Bacteria - 482; Metazoa - 2236; Fungi - 1004; Plants - 1936; Viruses - 0; Other Eukaryotes - 1025 (source: NCBI BLink).
